GC9009 Chitosan, low molecular weight

Synonyms: Deacetylated chitin; Poly(D-glucosamine)

Structure for Chitosan, low molecular weight (9012-76-4)

Structure for Chitosan, low molecular weight (9012-76-4)

CAS: 9012-76-4

MF: (C₆H₁₁NO₄)n

MW: ~50,000

Availability: In stock

GC9009 Chitosan, low molecular weight

Synonyms: Deacetylated chitin; Poly(D-glucosamine)

CAS: 9012-76-4 MF: (C₆H₁₁NO₄)n MW: ~50,000

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Chitosan is a polysaccharide comprised of linked D-glucosamine and N-acetyl-D-glucosamine units. It is produced by the deacetylation of chitin, a naturally occurring polysaccharide. Chitosan is commercially used in agriculture as a biopesticide but has potential applications in the biomedical field due to its antibacterial properties. This product is derived from shrimp shell.

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Citations (6)

Glentham Code

GC9009

Product Categories

APIs Carbohydrates Biochemicals Natural Products Polysaccharides Oligosaccharides Chitin & Chitosan

CAS RN

9012-76-4

EC Number

618-480-0

MDL Number

MFCD00161512

Storage Temperature

+20°C

Shipping Temperature

Ambient

Harmonised Tariff Code

39139000

Physical Description

Off-white to light brown or yellow powder

Water

≤ 10.0%

Ash

≤ 2.0%

Viscosity

≤ 100mPa.s

Heavy Metals

≤ 10ppm

Specification Version

1.0

Not classified as a hazardous substance or mixture

If you are publishing research using GC9009 please contact us to contribute to our list of citations.

Oral Pharmacokinetics of a Chitosan-Based Nano- Drug Delivery System of Interferon Alpha
Julieta C. Imperiale, Inbar Schlachet, Marianela Lewicki, Alejandro Sosnik, Mirna M. Biglione
Polymers, 1862, 11(11) (2019)

Interferon alpha (IFNα) is a protein drug used to treat viral infections and cancer diseases. Due to its poor stability in the gastrointestinal tract, only parenteral administration ensures bioavailability, which is associated with severe side effects. We hypothesized that the nanoencapsulation of … read more

Chitosan-graft-poly(methyl methacrylate) amphiphilic nanoparticles: Self-association and physicochemical characterization
Inbar Schlachet, Jiří Trousil, Dmytro Rak, Kenneth D. Knudsen, Ewa Pavlova, Bo Nyström, Alejandro Sosnik,
Carbohydrate Polymers,, 412-420, 212 (2019)

In this work, we synthesized and characterized the self-assembly behavior of a chitosan-poly(methyl methacrylate) graft copolymer and the properties of the formed nanoparticles by static and dynamic light scattering, small-angle neutron scattering, and transmission electron microscopy. Overall, our… read more

Mixed Amphiphilic Polymeric Nanoparticles of Chitosan, Poly(vinyl alcohol) and Poly(methyl methacrylate) for Intranasal Drug Delivery: A Preliminary In Vivo Study
Inbar Schlachet, Hen Moshe Halamish, Alejandro Sosnik
Molecules, 4496, 25(19) (2020)

Intranasal (i.n.) administration became an alternative strategy to bypass the blood–brain barrier and improve drug bioavailability in the brain. The main goal of this work was to preliminarily study the biodistribution of mixed amphiphilic mucoadhesive nanoparticles made of chitosan-g-poly(methyl m… read more

Nanoparticle-in-microparticle oral drug delivery system of a clinically relevant darunavir/ritonavir antiretroviral combination
Robin Augustine, Dana Levin Ashkenazi, Roni Sverdlov Arzi, Vita Zlobin, Rona Shofti, Alejandro Sosnik
Acta Biomaterialia, 344-359, 74 (2018)

Nanonization has been extensively investigated to increase the oral bioavailability of hydrophobic drugs in general and antiretrovirals (ARVs) used in the therapy of the human immunodeficiency virus (HIV) infection in particular. We anticipated that in the case of protease inhibitors, a family of p… read more

Smart thermosensitive copolymer incorporating chitosan–zinc–insulin electrostatic complexes for controlled delivery of insulin: effect of chitosan chain length
Divya Sharma, Sanjay Arora, Jagdish Singh
International Journal of Polymeric Materials and Polymeric Biomaterials, 1054-1068, 69(16) (2020)

This work was designed to optimize the thermosensitive copolymeric depot-based system for delivering insulin at a controlled rate for a prolonged period following a single subcutaneous injection. The intrinsic ability of insulin to form hexamers in the presence of zinc and electrostatic complexes w… read more

Cannabidiol-Loaded Mixed Polymeric Micelles of Chitosan/Poly(Vinyl Alcohol) and Poly(Methyl Methacrylate) for Trans-Corneal Delivery
Alejandro Sosnik, Ronya Ben Shabo and Hen Moshe Halamish
Pharmaceutics, 2142, 13(12) (2021)

Ocular drug delivery is challenging due to the very short drug residence time and low permeability. In this work, we produce and characterize mucoadhesive mixed polymeric micelles (PMs) made of chitosan (CS) and poly(vinyl alcohol) backbones graft-hydrophobized with short poly(methyl methacrylate) … read more

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