Physical Description
White to light-tan powder
Degree of Deacetylation
≥ 90.0%
Viscosity (1% in 1% AcOH, 20°C)
≤ 5cps
Solubility (in acetic acid)
≥ 99%
pH (1% in water, 20°C)
6.0 - 8.0
Yeast and Mould
≤ 100CFU/g
Total Plate Count
≤ 1000CFU/g
Specification Version
1.1
Not classified as a hazardous substance or mixture
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Preparation and Properties of Hydrogel Microparticles Based on Chitosan
A. N. Kraskouski, V. V. Nikalaichuk, V. I. Kulikouskaya, K. S. Hileuskaya, J. N. Kalatskaja, E. L. Nedved, N. A. Laman, V. E. Agabekov
Theoretical and Experimental Chemistry, Pages 243-251, 56 (2020)
Positively charged (zeta potential 22-31 mV) hydrogel microparticles based on low and high molecular weight
chitosan were synthesized. The effect of the crosslinking agent on their physicochemical characteristics was
studied. It was established, that among obtained hydrogel particles, the ones ba…
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QbD based development of resveratrol-loaded mucoadhesive lecithin/chitosan nanoparticles for prolonged ocular drug delivery
Mithun Saha, Diti Rani Saha, Tahamina Ulhosna, Shazid Md Sharker, Md Hasanuzzaman Shohag, Muhammad Saiful Islam, Swapan K. Ray, G.M Sayedur Rahman, Hasan Mahmud Reza
Journal of Drug Delivery Science and Technology, 102480, 63 (2021)
The lower drug retention to the eye's anterior portion is a prime concern in the ocular drug delivery system. To improve the drug retention capacity, we aimed to develop drug–containing nanoparticles using Quality by Design (QbD) approach. The current study describes the development of resveratrol-…
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pH-Sensitive Chitosan Nanoparticles for Salivary Protein Delivery
Yi Zhu, Lina M. Marin, Yizhi Xiao, Elizabeth R. Gillies, Walter L. Siqueira
Nanomaterials, 1028, 11(4) (2021)
Salivary proteins such as histatins (HTNs) have demonstrated critical biological functions directly related to tooth homeostasis and prevention of dental caries. However, HTNs are susceptible to the high proteolytic activities in the oral environment. Therefore, pH-sensitive chitosan nanoparticles …
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Prediction of coating thickness for polyelectrolyte multilayers via machine learning
Varvara Gribova, Anastasiia Navalikhina, Oleksandr Lysenko, Cynthia Calligaro, Eloïse Lebaudy, Lucie Deiber, Bernard Senger, Philippe Lavalle & Nihal EnginVrana
Scientific Reports, 18702, 11 (2021)
Layer-by-layer (LbL) deposition method of polyelectrolytes is a versatile way of developing functional nanoscale coatings. Even though the mechanisms of LbL flm development are well-established, currently there are no predictive models that can link flm components with their fnal properties. The cu…
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Chitosan-capped silver nanoparticles: A comprehensive study of polymer molecular weight effect on the reaction kinetic, physicochemical properties, and synergetic antibacterial potential
Viktoryia Kulikouskaya, Kseniya Hileuskaya, Aliaksandr Kraskouski, Irina Kozerozhets, Elena Stepanova, Ivan Kuzminski, Lijun You, Vladimir Agabekov
SPE Polymers, Pages 77 - 90, 3(2) (2022)
The search for novel efficient antibacterial agents is attracting a great attention due to the unregulated use of common antibiotics and development of multidrug-resistant bacteria strains. This paper proposes an eco-friendly approach to obtain stable chitosan-capped silver nanoparticles with contr…
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